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1994-09-24
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Document 0750
DOCN M9490750
TI Serum carotene deficiency in HIV-infected patients. Berlin
Diarrhoea/Wasting Syndrome Study Group.
DT 9411
AU Ullrich R; Schneider T; Heise W; Schmidt W; Averdunk R; Riecken EO;
Zeitz M; Department of Medicine, Klinikum Steglitz, Free University of;
Berlin, Germany.
SO AIDS. 1994 May;8(5):661-5. Unique Identifier : AIDSLINE MED/94338603
AB OBJECTIVE: To assess total serum carotene concentration in HIV-infected
patients as an indicator of fat malabsorption in correlation with
diarrhoea, secondary enteric infections, and blood lymphocyte subsets.
DESIGN: Prospective study. SETTING: Two referral-based tertiary care
centres in Berlin, Germany. PATIENTS: A total of 33 controls and 116
HIV-infected patients who had complete microbiological evaluation of
stools and biopsies obtained at upper endoscopy because of diarrhoea (n
= 54), or other symptoms (n = 62), were studied. MAIN OUTCOME MEASURES:
Total serum carotene concentration was determined
spectrophotometrically. RESULTS: Total serum carotene concentration was
abnormal (< 0.88 mumol/l) in 77% of HIV-infected patients and
significantly decreased compared with controls [0.47 mumol/l (range,
0.06-1.69 mumol/l) versus 1.37 mumol/l (range, 0.88-2.92 mumol/l); P <
0.0001]. Total serum carotene concentration did not differ between AIDS
patients and patients at earlier disease stages, between patients with
or without secondary enteric infections, or between patients with or
without fever. In patients at earlier disease stages, but not in AIDS
patients, total serum carotene concentration was lower for patients with
than without diarrhoea. The percentage of CD4 lymphocytes (r = 0.364; P
< 0.001), CD4 count (r = 0.28; P = 0.0013), and CD4/CD8 ratio (r = 0.38;
P < 0.001) in the peripheral blood correlated with total serum carotene
levels in HIV-infected patients. CONCLUSION: HIV-infected patients
frequently have abnormal total serum carotene concentrations indicating
fat malabsorption which may contribute to diarrhoea. Furthermore, total
serum carotene concentrations correlate with immunologic abnormalities
in HIV infection.
DE Carotene/BLOOD/*DEFICIENCY Diarrhea/COMPLICATIONS Dietary
Fats/PHARMACOKINETICS Female Human HIV
Infections/*BLOOD/COMPLICATIONS Intestinal
Diseases/COMPLICATIONS/MICROBIOLOGY Intestinal Diseases,
Parasitic/COMPLICATIONS Leukocyte Count Malabsorption
Syndromes/BLOOD/COMPLICATIONS Male Prospective Studies Support,
Non-U.S. Gov't T4 Lymphocytes JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).